So, many of the people who took Z-Packs because they thought it was their only choice may have been perfectly fine just getting the penicillin instead, making them even more egregiously overprescribed. At this point, research estimates that up to 98 percent of group A streptococcus are resistant to azithromycin worldwide, Dr. Vijayan says. So, no, a Z-Pack is not the first-line option for strep throat, even if it’s easy. Z-Pack antibiotics, we were told, were safe and effective at treating approximately a billion different conditions. And why am I stuck with long, boring courses of other antibiotics nowadays instead? As a service to our readers, Harvard Health Publishing provides usage of our library of archived content.
Tissue levels were determined carrying out a single oral dose of 500 mg azithromycin in 7 gynecological patients. Approximately 17 hr after dosing, azithromycin concentrations were 2.7 mcg/g in ovarian tissue, 3.5 mcg/g in uterine tissue, and 3.3 mcg/g in salpinx. Carrying out a regimen of 500 mg on the first day accompanied by 250 mg daily for 4 days, concentrations in the cerebrospinal fluid were less than 0.01 mcg/mL in the occurrence of non-inflamed meninges.Continue Reading